ERIC Number: EJ1156898
Record Type: Journal
Publication Date: 2017-Nov
Abstractor: As Provided
Symptoms of Autism Spectrum Disorder (ASD) in Individuals with Mucopolysaccharide Disease Type III (Sanfilippo Syndrome): A Systematic Review
Wolfenden, C.; Wittkowski, A.; Hare, D. J.
Journal of Autism and Developmental Disorders, v47 n11 p3620-3633 Nov 2017
The prevalence of autism spectrum disorder (ASD) in many genetic disorders is well documented but not as yet in Mucopolysaccharidosis type III (MPS III). MPS III is a recessively inherited metabolic disorder and evidence suggests that symptoms of ASD present in MPS III. This systematic review examined the extant literature on the symptoms of ASD in MPS III and quality assessed a total of 16 studies. Results indicated that difficulties within speech, language and communication consistent with ASD were present in MPS III, whilst repetitive and restricted behaviours and interests were less widely reported. The presence of ASD-like symptoms can result in late diagnosis or misdiagnosis of MPS III and prevent opportunities for genetic counselling and the provision of treatments.
Descriptors: Autism, Pervasive Developmental Disorders, Genetic Disorders, Symptoms (Individual Disorders), Comorbidity, Literature Reviews, Speech Impairments, Language Impairments, Communication Problems, Behavior Disorders, Interests, Clinical Diagnosis, Observation, Diagnostic Tests, Child Development, Infants, Cognitive Ability, Intelligence Tests, Interpersonal Competence, Personality Measures
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A
Identifiers - Assessments and Surveys: Autism Diagnostic Observation Schedule; Bayley Scales of Infant Development; Stanford Binet Intelligence Scale; Vineland Social Maturity Scale
Grant or Contract Numbers: N/A