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ERIC Number: EJ1156821
Record Type: Journal
Publication Date: 2017-Nov
Pages: 12
Abstractor: As Provided
ISSN: ISSN-0162-3257
Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development
Wiggins, Lisa D.; Tian, Lin H.; Levy, Susan E.; Rice, Catherine; Lee, Li-Ching; Schieve, Laura; Pandey, Juhi; Daniels, Julie; Blaskey, Lisa; Hepburn, Susan; Landa, Rebecca; Edmondson-Pretzel, Rebecca; Thompson, William
Journal of Autism and Developmental Disorders, v47 n11 p3634-3645 Nov 2017
The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: "mild language delay with cognitive rigidity," "mild language and motor delay with dysregulation," "general developmental delay," and "significant developmental delay with repetitive motor behaviors." We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed.
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Publication Type: Journal Articles; Reports - Research
Education Level: Early Childhood Education
Audience: N/A
Language: English
Sponsor: Centers for Disease Control and Prevention (DHHS/PHS)
Authoring Institution: N/A
Grant or Contract Numbers: U10DD000180; U10DD000181; U10DD000182; U10DD000183; U10DD000184; U10DD000498