Infants are born primed to develop attachment relationships. However, when infants are hospitalized in the neonatal intensive care unit at birth, the stress and trauma associated with the highly specialized medical environment can threaten the development of a nurturing and secure caregiving relationship. Infant mental health is an evidence-based field of practice that focuses on fostering this relationship. This article presents the design, piloting, and implementation of the Stein Tikun Olam Infant-Family Mental Health Initiative at the Newborn and Infant Critical Care Unit at Children's Hospital Los Angeles. It includes clinical and educational services and illustrates the benefits, challenges, and lessons learned.