Research institutions are charged with developing and managing conflict of interest (COI) policies regarding the design, conduct, and reporting of research. Prior research indicates that university researchers may not understand the purpose of these policies and may resent the time taken to demonstrate compliance. Policy communication is not a simple issue, nor is it a process clearly defined in the COI context. Accordingly, this study investigates multiple aspects of policy communication across disciplines to shed light on policy communication practices as well as on how communication relates to policy knowledge and attitudes. Specifically, this study investigates COI policy communication, knowledge, and attitudes at a large university and compares differences across disciplines. Using the framework of structurating activity theory, the study also analyzes how norms for ethical conduct differ across disciplines and correlate with policy communication, knowledge, and attitudes. A total of 246 participants representing health sciences and non-health sciences disciplines participated in an online survey regarding the institution's COI policies. Results indicate that attitudes toward the COI policies are positive across disciplines and that policy knowledge is higher than mid-range. However, policy communication is low across disciplines, with non-health sciences participants reporting lowest levels of communication about the policy. Implications and recommendations are offered for future research and research administration practice.