This study investigated the effects of teaching gardening on science students' attitudes toward entrepreneurial skills acquisition in Jos South, Plateau State, Nigeria. The study employed the non-randomized pre-test post-test non-equivalent control group design. A sample of 75 senior secondary school students from two intact classes, randomly assigned to an experimental group (n = 38) and a control group (n = 37) was used for the study. An entrepreneurial attitude orientation scale was used to collect data for analysis. The findings indicated that the experimental group exposed to gardening activities showed positive attitudes toward acquiring entrepreneurial skills unlike the control group. However, gender was found not to be a significant factor in students' attitudes toward entrepreneurial skills acquisition. It was concluded that teaching gardening has a significant effect on students' attitudes toward entrepreneurial skills acquisition. It is recommended that students should be taught gardening to enhance their attitudes toward entrepreneurial skills acquisition for self-reliance, among others.