This cross-sectional study provides a general profile of mothers of children with ASDs in Kuwait and examines their use of social support resources and coping strategies (using the Brief COPE questionnaire). The majority of mothers reported decreased ability to perform social duties (62.4%) and take care of themselves (50.5%). Overall, 57.7% of mothers reported a decreased ability to enjoy life; this difference was more pronounced among non-Kuwaiti mothers compared to Kuwaiti mothers (p value = 0.03), and in mothers with a bachelor's degree or higher (p value = 0.011). There was a significant association between the mothers' ability to enjoy life and receiving support from the family (p value = 0.021) and support groups (p value = 0.003). "Religion", "Acceptance", and "Positive Reframing" were the 3 most common coping strategies.