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ERIC Number: EJ1154143
Record Type: Journal
Publication Date: 2017-Sep
Pages: 4
Abstractor: As Provided
ISSN: ISSN-0021-9584
Cross-Course Collaboration in the Undergraduate Chemistry Curriculum: Isotopic Labeling with Sodium Borodeuteride in the Introductory Organic Chemistry Laboratory
Kjonaas, Richard A.; Fitch, Richard W.; Noll, Robert J.
Journal of Chemical Education, v94 n9 p1334-1337 Sep 2017
A microscale isotopic labeling experiment is described for the introductory organic chemistry laboratory course wherein half of the students use sodium borohydride (NaBH[subscript 4]) and the other half use sodium borodeuteride (NaBD[subscript 4]) to reduce acetophenone to 1-phenylethanol and then compare spectral data. The cost is reasonable, and the experiment is well-suited to serve as a first experience with [superscript 1]H NMR spectroscopy, infrared spectroscopy, and/or mass spectrometry. No special apparatus are required for the reaction. The entire experiment, including an extensive prelab lecture and acquisition of [superscript]1 H NMR data, is completed in a 3 h period. The experiment can stand alone, but lends itself to cross-course collaboration between the organic and physical chemistry laboratories. The succeeding companion article describes the measurement of a kinetic isotope effect using the product from this experiment. The physical chemistry students report their experimental results back to the organic class.
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: National Science Foundation (NSF)
Authoring Institution: N/A
Grant or Contract Numbers: DUE0942345