This study used the actor-partner interdependence mediation model to examine the association among parents' depressive symptoms, sense of mastery, and parent involvement. To address the research goal, this study conducted secondary analysis using the cross-sectional data collected from the 2000 cohort of the Head Start Family and Child Experiences Survey. Both mothers and fathers with children enrolled in Head Start programmes completed the phone interviews and questionnaires. Results showed that sense of mastery significantly mediated the association between parents' depressive symptoms and Head Start involvement for both parents. Specifically, mothers' increased depressive symptoms were related to lower sense of mastery, which in turn was related to fathers' increased involvement at Head Start. Implications of this study and future research are discussed.