Stress poses one of the biggest threats to the health and well-being of young people. Adolescents are especially vulnerable to the negative effects of stress due to developmental factors. Recently, Mindfulness Meditation (MM) programs have been implemented into both clinical and school-based settings to reduce stress and promote the health of adolescents. This article reviews the current literature that reports on the effect of MM to reduce adolescent stress and enhance well-being. Results appear promising for MM to positively affect the identified outcomes in both clinical and school settings. Recommendations for schools to implement MM within the framework of a Coordinated School Health Program are included.