Weight-related teasing is associated with reduced levels of physical activity in youth, but the importance of weight teasing experiences to the engagement of female college students in physical activity is yet to be determined. Thus, this study examined differences in physical activity engagement and physical activity enjoyment in female college students with and without a prior history of weight-related teasing. Ninety female college students participated in the study. Participants wore accelerometers for seven days, and completed the Physical Activity Enjoyment Scale and the Perception of Teasing Scale. A body impedance scale assessed body composition. Independent t-tests compared participants with and without a prior history of weight-related teasing for the dependent variables body fat percentage, physical activity enjoyment, and physical activity engagement. Approximately 37% of the participants reported prior weight-related teasing experiences. Female college students with a previous experience of weight-related teasing accumulated significantly fewer minutes of vigorous physical activity (p = 0.026), showed lower levels of physical activity enjoyment (p = 0.005), and had a higher percentage of body fat (p = 0.001) than their counterparts without a history of weight-related teasing. Weight-related teasing was a determinant factor for the participation of female college students in physical activity