The purpose of this study was to investigate the relationship between indoor environmental quality (IEQ) in a set of university classrooms and students' outcomes, i.e., satisfaction with IEQ, perceived learning, and course satisfaction. Data collected from students (N = 631) of University of Minnesota were analyzed to test a hypothesized conceptual model by conducting a path analysis. Findings suggested that IEQ of the classrooms, such as thermal conditions, indoor air quality, acoustic conditions, lighting conditions, furnishings, aesthetics, technology, and view conditions, was associated with positive student outcomes. Implications for classroom design were discussed with suggestions for future research.