In this article, the authors discuss how one public high school became a site for socio-politically relevant pedagogy for immigrant and refugee youth, building on the concept of culturally relevant pedagogy that has been discussed in educational scholarship (Howard, 2001, 2003; Ladson-Billings, 1994, 1995a, 1995b). By exploring newcomer youth's understandings of their experiences, self-conceptions, and positioning in the global economy, the authors draw on a three-year qualitative case study utilizing ethnographic methods to highlight the key tenets of a socio-politically relevant pedagogy for youth who lead transnational lives. The key tenets proposed include: (1) the cultivation of critical consciousness around global inequalities and transnational migration; (2) the creation of formal and informal avenues for reciprocal learning between families/communities and schools; and (3) support and care for the material conditions of students' and families' lives.