We may define and prioritize them differently, but few would deny that our human community is facing intractable problems at local, national, and global scales. The authors call on higher education institutions (HEIs) around the world to work collectively and with strategic intent and action to use sustainability as an organizing principle to focus service-learning and community engagement (SLCE) activities on the flourishing of our planet and its diverse species. While certainly not perfect and still in an emergent phase, efforts such as those being undertaken by colleges and universities described in this article are beginning to generate significant results by utilizing sustainability as an overarching institutional organizing principle and SLCE strategies as the delivery mechanisms for realizing change on their campuses and in their communities.