Love, as an essential motif in life, may be expressed in various forms based on the cultural identities of the people expressing it. The concept of love in "Love in the Time of Cholera" is demonstrated by the two forms of romantic and elusive love. The book is a mirror of the cultural and traditional values of the late 19th and early 20th centuries in Colombia. The rejection of the catholic faith, and religion in general, can be considered a central argument of the story. The poetic language and the precise descriptions expand the narrative's attraction. The concept of love in Persian literature , on the other hand, is a reflection of virtue and devotion, i.e. "virtual /earthly love is a bridge to real/heavenly love" a philosophy attributed to renowned Iranian scientists Avicenna and Mulla Sadra. Iranian cultural values and Islamic instructions for religious morality have been integrated in each other for fourteen centuries. In the Quranic Surah of "Yusuf," love is a means by which Joseph/Yusuf is tested by God to be granted a higher divine position. This concept of love is an ingrained notion in Persian literature. This essay compares the concept of love in the Colombian and Iranian cultures. The two main parts of this essay deal with "Love in the Time of Cholera" and Persian literary works from early times to modern day.