This study investigated the effect of mathematics innovation and technology on students' academic performance in open and distance learning. Quasi -- experimental research design was adopted for the study. The population for the study consisted of all the 200 level primary education students at the National Open University of Nigeria (Ekiti and Lagos State Chapter).The sample of this study was made of 60 students randomly selected using stratified sampling technique. Hypotheses were postulated to find out whether, (i) mathematics innovation and technology influences academic performance of open and distance learning students (ii) location and gender disparity influences academics performance of students in mathematics. The study became necessary following the emerging trend of National University Commission (NUC) in sustaining the development of National Open University of Nigeria (NOUN by) ensuring human capacity building at workplace. The study revealed that mathematics innovation, location, gender and technology influences academic performance of students in mathematics. Based on the findings it is recommended that mathematics innovation and technology should be embraced in Open and Distance Learning so as to enhance better performance of students in mathematics.