In this research, the relational coordination model has been applied to prove learners' and instructors' high levels of satisfaction in e-learning. According to the model, organizations can obtain better results in terms of satisfaction by providing shared knowledge, shared goals and mutual respect mechanisms, supported by a frequent, timely and problem-solving communication. Online courses learners and instructors from Spanish universities and private companies have been surveyed on these particular issues. By using structural equation model analysis, it is shown that high standards in terms of relational coordination amongst learners and instructors explain higher degrees of satisfaction. This research contributes to the literature by validating from an empirical point of view the effects of the use of the relational coordination model in e-learning. The results should be considered by universities and private companies when they evaluate the results of their actual e-learning systems and search for the improvement of quality.