Objectives: The objectives of this study were to: (1) examine changes in stress during first semester among freshmen undergraduates and (2) identify predictors of stress (coping strategies, emotional states, and quality of sleep). Participants: One hundred ninety-seven freshmen students were recruited for a 10-week study during first quarter (October-December, 2015). Methods: Students completed weekly self-report surveys on stress, coping strategies, emotions, and quality of sleep. A generalized linear mixed model was used for analyses. Results: Stress was elevated during examinations periods. Women reported a greater stress level than men. Increased stress level was significantly associated with lower sleep quality and greater negative emotions (fear, anger). Exercise was an effective stress coping strategy, while other coping methods (Internet usage, meditation, and self-isolation) were associated with higher stress. Social media usage did not influence stress level. Conclusions: Future stress management programs for freshmen need to consider gender differences and may focus on sleep, exercise, and decreased general Internet usage.