Learning taxonomies can assist faculty in developing course structures that promote enhanced student learning in the cognitive and affective domains. Significant Learning is one approach to course design that allows for development in six key areas: Foundational Knowledge, Application, Integration, Human Dimension, Caring, and Learning How to Learn. These six dimensions can be explored in a non-hierarchical manner, which enables faculty to choose a particular area of concentration without a strict progression of learning. This paper will highlight the value of developing Significant Learning strategies in undergraduate education.