The authors report on the results of a survey conducted in the United States on collaboration between Centers for Teaching and Learning (CTLs) and Offices of Disability Services (ODSs) in institutions of higher education. The authors, a disability services professional and a former director of a Center for Teaching and Learning, give particular attention to the current collaborative efforts occurring between these two offices as well as the perceived challenges of those collaborative efforts. Significant findings from the survey results include five key challenges to collaboration between ODSs and CTLs: (1) time and logistics; (2) faculty-related challenges; (3) competing priorities; (4) changing the campus culture; and (5) funding and limited resources.