The phenomenon of sedentary lifestyle has become a dangerous issue with serious health consequences in modern time. Modern technology has contributed, in no small measure, to a sedentary lifestyle of many individuals with attendant physical, physiological and social health hazards. As a result of lack of regular exercises, many people are now battling with obesity, diabetes, hypertension and overweight. This paper examines the concept of sedentary lifestyle, reasons for sedentary lifestyle, consequences of sedentary lifestyle and the use of regular physical activity to ascertain healthful living and longevity.