The current state attaches great importance to college entrepreneurship education, but entrepreneurship education should combine with college students' professional learning. Different professional learning backgrounds have commonalities in entrepreneurship education; there may be differences, too. Various professional knowledge background and professional characteristics make different students possess diverse knowledge structure and skill resource, so the key factors needed in the entrepreneurship process may be different. This article proposes "STI+" model, the so-called STI refers to professional learning and can be divided into social science, technical science and natural science. The "STI+" model is based on various profession to carry out entrepreneurship education. Based on this, we separate "STI+" model into three types and select representative universities to do analysis and research, then sum up how schools of diverse professional background develop entrepreneurship education.