This conceptual article synthesizes the empirical research on punitive environmental norms of schools and the disproportionate effects on certain child and adolescent groups, particularly within urban schools. This involvement has come to be known as the school-to-prison pipeline. The young people affected by harsh school discipline protocols and involved formally with the juvenile courts share a number of common vulnerabilities. A review of these common risk factors that children and adolescents experience is presented first. This is followed by identification of which child and adolescent groups are disproportionately involved in the pipeline: the impoverished, those of color, maltreatment victims, students with special education disabilities, and lesbian, gay, bisexual, and transgender.