As the United States population approaches a minority majority, the need to address educational inequities is intensified, especially for Latin@ students who are among the fastest growing ethnic minority group across the United States and at four-year colleges and universities. Concerns for educational equity also demand broadening participation of domestic under-represented groups in science, technology, engineering, and mathematics (STEM) fields. Informed by student-level data from six large, public, doctoral-granting, research-intensive universities located in the Midwest and Mid-Atlantic regions, we examine differences in STEM degree attainment among Latin@s at the intersections of race/ethnicity, gender, and socioeconomic status. The results support the need to target STEM intervention efforts to Latin@s by gender.