The underrepresentation of women in academe has been the focus of both academic literature and European policy-makers. However, albeit the number of female scientists has increased, true gender equality has yet to be achieved. When examining the reasons for this, we have to consider the interconnection between the expectations surrounding gender and what it means to work in the scientific profession, operating at individual, interactional, and institutional levels. This paper presents the results (and methods) of a survey exploring work-life interfaces from a gender-sensitive perspective. Our survey focused on the researchers and professors working in the medicine and engineering departments of the University of Pisa, where the gradient of female exclusion is most pronounced. The results allow for an interpretation of the "leaky pipeline" (macro level), through a gender-sensitive analysis of gender-based social obligations and those associated with the scientific profession (micro perspective), by integrating said reading through a description of the dynamics of continuous negotiation in private and public life (university) (meso level). Essentially, science is a greedy institution, as is family life, which is a problem for a woman's career, unless she is willing to make considerable concessions at home.