This study examined the impact of a one-to-one iPad program on inquiry-based instruction (IBI) in an all-girls science, technology, engineering, and mathematics-focused school with 99% African American students. Case study research was used and included three teachers at the school for the purpose of this study. Data collection included pre- and post-interviews and 27 classroom observations. The Electronic Quality of Inquiry Protocol (EQUIP) was used to evaluate the quality of inquiry-based instruction. The EQUIP rubric is aligned with the National Research Council's definition for inquiry-based instruction, and made the tool particularly helpful for this study. The study identified two major themes related to the impact of a one-to-one environment on IBI. Teachers were able to use the technology to enhance their IBI, and the ways in which (how) they used the technology also had a significant impact on the quality of their IBI.