In this study, an evidence-based program aiming to promote psychological well-being and resilience within the context of Greek schools is presented. It is based upon a multidimensional model that synthesizes different theoretical domains, placing emphasis on different goals depending on the needs of the school community during unsettling times. Culture-specific characteristics of the economic recession are addressed, using a multilevel mixed-model participatory design, including needs assessment, pre-assessment and post-assessment. Overall assessment supported the program's effectiveness on teachers' resilience, students' goal setting, and the promotion of a positive school climate.