ERIC Number: EJ1141219
Record Type: Journal
Publication Date: 2017-Jun
Abstractor: As Provided
Autism Spectrum Disorder Symptoms in Infants with Fragile X Syndrome: A Prospective Case Series
Hogan, Abigail L.; Caravella, Kelly E.; Ezell, Jordan; Rague, Lisa; Hills, Kimberly; Roberts, Jane E.
Journal of Autism and Developmental Disorders, v47 n6 p1628-1644 Jun 2017
No studies to date have prospectively examined early autism spectrum disorder (ASD) markers in infants with fragile X syndrome (FXS), who are at elevated risk for ASD. This paper describes the developmental profiles of eight infants with FXS from 9 to 24 months of age. Four meet diagnostic criteria for ASD at 24 months of age, and four do not. Trends in these case studies suggest that early social-communicative deficits differentiate infants with and without later ASD diagnoses in ways that are similar to later-born siblings of children with ASD. Repetitive behaviors and cognitive and adaptive impairments are present in all FXS infants throughout development, suggesting that these deficits reflect the general FXS phenotype and not ASD in FXS specifically.
Descriptors: Autism, Pervasive Developmental Disorders, Symptoms (Individual Disorders), Infants, Intellectual Disability, Case Studies, Profiles, Child Development, Toddlers, Clinical Diagnosis, Communication Problems, Interpersonal Competence, Evaluation Criteria, Genetics, Behavior Problems, Siblings, Genetic Disorders
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Sponsor: National Institute of Mental Health (DHHS/NIH)
Authoring Institution: N/A
Grant or Contract Numbers: R01MH0901194; R01MH107573