Technological Pedagogical Content Knowledge (TPACK) is a conceptual framework for teachers to teach effectively using technology. This framework originates from the opinion that use of technology in educational context would be effective only if content, pedagogy and technology are aligned carefully. It implies that for teachers to use technology in their teaching, they need to be competent in all three domains. This present paper is an attempt to understand the assumptions and components of Technological Pedagogical and Content Knowledge (TPACK) as a conceptual framework. Further, the paper addresses the issues and challenges in preparing teachers with TPACK capabilities, apart from emphasizing the role of teacher educators, pre-service, and in-service teachers in understanding TPACK for effective classroom teaching and learning. Suggestions for developing TPACK competencies among teacher educators, inservice teachers, and preservice teachers were discussed. Recommendation for restructuring curriculum of teacher training programmes was also included.