This paper examines individual and institutional characteristics which may influence the outcomes of university students' careers. Withdrawals, course changes, delays and graduations of students enrolled in first-cycle degree courses in a large public university in Italy are examined. Individual longitudinal data from administrative archives were used, taking into account both the temporal dimension and the organisational and structural characteristics of the degree courses. Results indicate that the profile of a successful student is defined by both socio-demographic factors and pre-university educational experience. At course level, restricted access to courses, study fields and course size were important for students' university careers.