This study was designed to examine the use of mobile phone, a widespread technology, and determined how this technology influences science students' learning. The study intended to examine the use of smartphones in science teaching and learning and propose of model in the use of smartphones for teaching and learning. The research design employed was a descriptive survey. The target population for the study was science students and lecturers from three selected public universities in Ghana. Five hundred and three students and 71 lecturers were selected for the sample size. Purposive and convenience sampling techniques were used in selecting the sample size. The data was collected using questionnaires from lecturers and students. Data was analyzed using descriptive statistics. Qualitative analysis from open ended items from the questionnaires were considered and inferences drawn from the opinions of the respondents. The findings revealed that the mobile phone had great potential as a learning tool and it could positively be used for teaching and learning purposes in science areas. After analyses the results were presented in the form of tables and bar charts. Discussion and conclusions were drawn. The study generated some useful data for lecturers and students to use for recommendations for policy.