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ERIC Number: EJ1136492
Record Type: Journal
Publication Date: 2017-Mar
Pages: 4
Abstractor: As Provided
ISSN: ISSN-0021-9584
Synthesis and Characterization of 2-Phenylimidazo[1,2-a]pyridine: A Privileged Structure for Medicinal Chemistry
Santaniello, Brandi S.; Price, Matthew J.; Murray, James K., Jr.
Journal of Chemical Education, v94 n3 p388-391 Mar 2017
A straightforward synthesis of 2-phenylimidazo[1,2-a]pyridine is described. The reaction is designed to demonstrate to students the preparation of a bridged N-heterocycle, in which the heteroatom occupies a bridgehead position. The product is obtained in moderate to high yield and is highly crystalline. The compound can be purified either by direct recrystallization or silica gel column chromatography. Students characterize the compound by melting point, MS, IR spectroscopy, and NMR spectroscopy. Spectroscopic analysis reveals features that are potentially suitable for more in-depth discussions.
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A