Can mastery and performance-approach goals predict distance learners' learning and achievement in different learning situations over an academic year? Using a prospective longitudinal design, the current study examined this research question using a cohort of distance learners in Hong Kong. Two hundred and seventy-two distance learners completed three survey questionnaires at the beginning, in the middle and towards the end of an academic year. Regression analyses found that distance learners' mastery and performance-approach goals at the beginning of the academic year predicted learning interest and the use of regulatory strategies in subsequent surveyed points after controlling for the effects of the age factor and self-efficacy levels.