This study seeks to explain what first- and second-grade African American, urban students who participated in an explicit comprehension strategy instruction (ECSI) program learned about comprehension strategies and how this knowledge supports self-regulated strategy use. The study was also designed to compare these students' knowledge with those who were exposed to less systematic comprehension strategy instruction. Students who participated in ECSI had more awareness and knowledge of strategies and applied them more frequently than students not in ECSI. A practitioner's framework is proposed to support teachers in developing their own ECSI.