Implementing and integrating an Enterprise Resource Planning (ERP) system into an organization is an enormous undertaking that requires substantial cash outlays, time commitments, and skilled IT and business personnel. It requires careful and detailed planning, thorough testing and training, and a change management process that creates a supporting culture. In rare circumstances is a company required to implement an ERP twice in two years. This teaching case documents the business process changes and ERP system related events that occurred to a pharmaceutical manufacturing facility when it was involved in an acquisition; and then, a second acquisition in less than a three year time period.