Purpose: To identify academic and demographic variables related to a successful outcome on the national certification exam for occupational therapists (National Board for Certification in Occupational Therapy [NBCOT] exam) at one academic institution with the expectation that it could be replicated with multiple institutions. Method: Binary logistic regression analyses were used to analyze three sets of academic and demographic predictors of the pass/retake outcome on the NBCOT exam. Results: Results of these analyses indicated that overall grade point average (GPA) and outcomes of specific academic coursework that was focused on practice application predicted passing the NBCOT examination on the first attempt. Conclusion: Results from this study illustrate the complexity in predicting performance on the NBCOT examination and the need to expand the predictors included in future analyses.