The processes for moving research-based knowledge to the domains of action in social policy and professional practice are complex. Several disciplinary research traditions have illuminated several key aspects of these processes. A more holistic approach, drawing on systems thinking, has also been outlined and advocated by recent contributors to this debate. This paper seeks to draw on these foundations to sketch a more integrated approach to nine organisational variables that influence the successful implementation of a "knowledge-to-action" framework for evidence-based policy and practice.