As Latino males are entering and graduating from higher education at significantly lower rates than their counterparts, this study focused on their educational coping processes. Interviews with five upper-division Latino male undergraduates at a large predominantly White 4-year university revealed a range of coping processes which were self-protective and that helped them persist to graduation. In particular, spirituality was explored as a central cultural coping mechanism, and results indicated that Latinos hold and understand different elements of their spirituality as a means to manage their educational experiences. Implications for gender- and culture-specific educational support for Latino undergraduates are addressed.