ERIC Number: EJ1131264
Record Type: Journal
Publication Date: 2017-Mar
Pages: 4
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-1072-0502
EISSN: N/A
ß-Adrenoceptor Activation Enhances L-Type Calcium Channel Currents in Anterior Piriform Cortex Pyramidal Cells of Neonatal Mice: Implication for Odor Learning
Ghosh, Abhinaba; Mukherjee, Bandhan; Chen, Xihua; Yuan, Qi
Learning & Memory, v24 n3 p132-135 Mar 2017
Early odor preference learning occurs in one-week-old rodents when a novel odor is paired with a tactile stimulation mimicking maternal care. ß-Adrenoceptors and L-type calcium channels (LTCCs) in the anterior piriform cortex (aPC) are critically involved in this learning. However, whether ß-adrenoceptors interact directly with LTCCs in aPC pyramidal cells is unknown. Here we show that pyramidal cells expressed significant LTCC currents that declined with age. ß-Adrenoceptor activation via isoproterenol age-dependently enhanced LTCC currents. Nifedipine-sensitive, isoproterenol enhancement of calcium currents was only observed in post-natal day 7-10 mice. APC ß-adrenoceptor activation induced early odor preference learning was blocked by nifedipine coinfusion.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
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