This article offers 10 guidelines for conducting international group work research. These guidelines include the importance of establishing relationships, conducting a needs assessment, co-constructing the research questions/design, determining the approach, choosing culturally relevant instruments, choosing culturally responsive group interventions, following required/ethical research procedures, determining data analysis/dissemination plan, engaging in effective communication, and practicing cultural humility throughout the process. Using a group stage conceptualization, a case study focusing on an international group work research effort being conducted in 2 primary schools in Malawi is given to highlight the guidelines.