Maternal depression influences home visiting engagement and outcomes. This article describes research which found that depressed mothers may be more likely to enroll in home visiting but are less likely to participate as long or as frequently as intended by programs. The authors found evidence of moderation (i.e., changes in the direction and strength of home visiting impacts on parenting outcomes for depressed mothers), although for some outcomes only one or two studies reported findings. Positive program impacts for depressed mothers were found for parenting and child behavioral and social-emotional development. research that illuminates pathways to outcomes for depressed mothers and other subgroups is needed to more effectively target engagement and prevention strategies that promote health for mothers and children.