A recent partnership between the Irving Harris Program in Child Development and Infant Mental Health and the Community Based Psychiatry Program at University of Colorado Hospital joined two different approaches to child mental health treatment: infant mental health and multisystemic therapy (MST). This article illustrates the compatibility of these two approaches by detailing the application of both models to the treatment of 4-year-old Noah and his substance-abusing mother, Kim. The authors highlight helpful aspects of each approach, such as using ecologically informed interventions (MST) and reflective practice (infant mental health) to show how openness to contrasting frameworks can ultimately benefit families.