Research indicates that up to half of mothers in home visiting experience clinically significant levels of depression during their participation in services. Depression alters maternal life course, negatively impacts child development, and contributes to poorer home visiting outcomes. This article describes the Moving Beyond Depression (MBD) program, an innovative and evidence-based approach to treating depressed mothers in home visiting. MBD uses In-Home Cognitive Behavioral Therapy, an empirically validated and collaborative intervention that overcomes barriers to treatment and contributes to recovery from depression and prevention of relapse. MBD has been successfully disseminated to other home visiting programs nationally.