Purpose: Insufficient physical activity leads to an increase in chronic diseases. Skills-based health education methods are supposed to be more successful than traditional methods to promote healthy behaviors. Skills-based health education is an approach to create healthy lifestyles and skills using participatory methods. The purpose of this paper is to examine the effects of skill-based education method on physical activities of female adolescents. Design/methodology/approach: This was an experimental study on 80 female public high school students aged 12-14 years old in Tehran. The participants were randomly divided into two groups: experimental group of 40 girls who were educated using "Skills-based education method," and control group of 40 girls who were educated by lecture as a routine educational method for health promotion. Data were collected using a valid and reliable questionnaire to assess physical activity-related knowledge, attitudes and behavior. Data were gathered three times; before, immediately after (Phase 1) and two months after educational intervention (Phase 2). Data analysis was performed using SPSS 20. Findings: Intra-group comparison demonstrated that both educational methods can increase knowledge, attitude and behavior of the students after intervention comparing to before intervention (RMANOVA; p<0.05). However, the comparison between groups demonstrated a significant higher increase of knowledge (t-test; p<0.01 and p<0.0; phase 1 and 2, respectively), and behavior (t-test; p<0.01 and p = 0.002; phase 1 and 2, respectively) but not attitude (p = 0.083 and p = 0.125, phase 1 and 2, respectively) among the students participated in the experimental "skilled based health education" group rather than the control "lecture" group. Originality/value: Skill-based health education comparing to routine lecture-based education creates deep and long lasting knowledge and behavior and is highly recommended for promoting physical activity and other health-related knowledge and among adolescents.