Introduction: The use of telehealth in service delivery is both challenging and beneficial. This paper describes the results of a three semester-long interprofessional education program in team-based care using telehealth technology. The study assessed telehealth knowledge acquisition, practice in a structured environment with a simulated patient, and application in an outpatient clinic. It involved 139 occupational therapy, physical therapy, and nurse practitioner students from a Midwestern university. It explored their perceptions of the telehealth process and how they perceived its influence on their therapeutic relationship with the patient and the telehealth team using a longitudinal pre-/post-test design. Methods: Knowledge about telehealth was tested with 16 multiple-choice questions. Attitudes and perceptions toward telehealth were assessed with 26 items of the Telemedicine Acceptance Questionnaire and through guided reflection. Quantitative data were analyzed using factor analysis, and qualitative data were analyzed for common themes. Results: Although students remained positive about telehealth, they found it to be less useful and less easy to use in both simulated and clinical settings. Discussion: Findings suggest that educators designing a curriculum that incorporates telehealth should include information on the perceived barriers it might create and ways to address them.