This research is a qualitative case research. The objects were eight senior high students taking information application program in Nan Oau Aboriginal Key Senior high school in Taiwan. The study was aim to design a project-based e-book making course for Nan Oau Aboriginal Key Senior high school by studying the Atayal handicraft art curriculums. The course had six units, including two free creation units, and three lessons per unit for a total of 18 lessons, 900 minutes. Collections of research data included the research notes, the teaching observation notes, the problem-solving examination forms, the e-book making evaluation forms, the interview outlines, and the students' learning sheets and homework. After collecting and cross analyzing the information, the main results were as follows: A) Most of the students were satisfied with this e-book making course. B) The students performed best in "the quality of problem solving", and "the attitudes of how they face problems" next. However, the ways how they "deal with problems" last, which should be enhanced. C) Their e-book works were all appreciated by professors, teachers, craftsmen, and students. During the problem-solving process, they faced problems with a positive attitude and displayed initiative and willingness to solve problems.