Color Vision Deficiency (CVD) is a commonly occurring condition in the general population. For medical students, it has the potential to create unique challenges in the classroom and clinical environments. Few studies have provided medical educators with comprehensive recommendations to assist students with CVD. This article presents a focused review of the literature about the impact of CVD on medical education. Universal Design for Instruction (UDI) principles are leveraged to identify and provide recommendations for mitigating the effects of CVD and rendering medical education curricula more accessible to all students regardless of their CVD status. Examples of recommendations for the classroom, lab, and clinical settings include: adjusting the color of laser pointers, providing high quality grayscale images alongside microscope images, and coaching around strategies for recognizing clinical indicators (instead of color-related signs). The experience of a prominent medical school in the United States, which was faced with a high number of first-year students with CVD and implemented these recommendations, is described. Other medical schools can similarly adapt and implement these recommendations within their own programs.