Cambodia has in the past 15 years been catching up with the global and regional trends of rapid expansion of higher education, but its specific socio-historical context has engendered particular life course and societal implications. Engaging with the current policy attention to the cause of skills mismatch in Cambodia, this article aims to provide a sociological perspective for understanding young people's decision-making about university majors. Framing the entrance into university study as a context of risks and uncertainties for the life course, the article draws on in-depth, biographical interviews with 31 university students in the Cambodian capital of Phnom Penh and analyses their decision-making about university majors by focusing on the person-situation interactions the students negotiate. Their approaches to university major selection involve individual agency and practical resources and constraints. They involve personal and interpersonal trust, intuition and emotion, which have implications for how skills mismatch in Cambodian higher education should be tackled.