This study investigated the relationship between dyslexia, homelessness, and drug use and dependency based on data from the Multiple Exclusion Homelessness Across the United Kingdom Survey, a national survey of 443 respondents who had experienced some form of homelessness in the U.K. Of particular interest was a comparison of the various experiences involving drug and dependency of homeless people with dyslexia vs. homeless people without dyslexia. The study revealed that individuals with dyslexia were overrepresented within the survey's homeless population. Furthermore, the findings indicated higher dependency problems as well as significant mental health problems for respondents with dyslexia compared to the nondyslexic homeless control group. Specifically, the dyslexic respondents were more likely to use methadone, were more susceptible to self-harm, and reported a higher rate of suicide attempts than the nondyslexic control group.