Telkom University was founded in 2013, as a result of merging four existing higher education institutions in Indonesia. One of their study programs is Master of Management (MM) program, which also facilitates full-time workers to participate in the program. Since their physical presences are sometimes unfulfilled, an e-learning program was implemented for the first time in 2014. This research was conducted to acknowledge the phenomena that Master of Management is the most favorite study program at Telkom University. The census data collection was conducted to each participant of Master of Management (MM) program, afterwards the problem-solving method used multiple linear regression. The independent variables are application-specific computer self-efficacy, Perceived usefulness, Interaction, and Social presence, while the dependent variable is e-learning effectiveness. The result showed that each independent variable effects on the dependent variable significantly. Independent variables simultaneously have significant influence on the dependent variable. Using percentage analysis technique, participants in distance learning programs at Telkom University argued that the l of implementation of the elements of distance learning 76%-88% are in the good-very good category. The elements of distance learning effect significantly influence the e-learning effectiveness at Telkom University.