Imagine a microscopic world filled with tiny motors, ratchets, switches, and pumps controlled by complex signaling and feedback systems. Now imagine that these parts can assemble themselves. This is the world presented to students in the protein structure unit of a genetic engineering course. Students learn how protein folding gives rise to the molecular machines in cells and how misfolding can lead to disease. Students also explore how scientists use the engineering design process to treat these diseases using rational drug design. The protein structure unit presents new problems to students who have learned about engineering through structural or mechanical challenges, such as bridges, mousetrap cars, or egg drops. It also draws in students interested in the life sciences who might not consider a typical engineering course. The authors hope the course makes cell biology less abstract for both types of students. This article describes a series of hands-on activities, online simulations, and computer-modeling programs that help students visualize protein structure and better understand protein function.